Mutant IDH1-IN-1

Catalog No.: A21359

mutant-selective IDH1 inhibitor

Mutant IDH1-IN-1

Mutant IDH1-IN-1 Chemical Structure

CAS NO. 1355326-21-4

Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $171.00

Special Price $136.80

10 mg

Regular Price: $295.00

Special Price $236.00

50 mg

Regular Price: $874.00

Special Price $699.20

100 mg

Regular Price: $1,748.00

Special Price $1,398.40

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Biological Activity

Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.06 mL 100.28 mL 200.57 mL
0.5 mM 4.01 mL 20.06 mL 40.11 mL
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL

*The above data is based on the productmolecular weight 498.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21359
Actions Inhibitor
CAS No. 1355326-21-4
Formula C30H31FN4O2
M. Wt 498.59
Purity >98%
SMILES O=C(C(C1=C(C)C=CC=C1)N(C(CN2C=NC3=C2C=CC=C3)=O)C4=CC(F)=CC=C4)NC5CCCCC5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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