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Mutant IDH1-IN-3

Name: Mutant IDH1-IN-3
Brand: Adooq Bioscience
SKU: A75813
Availability: OutOfStock

Cat. No. A75813 CAS 1648909-73-2

Mutant IDH1 Inhibitor

Mutant IDH1-IN-3 is a selective allosteric inhibitor of mutant isocitrate dehydrogenase 1 (IDH1), demonstrating an IC50 of 13 nM specifically for the R132H IDH1 variant. By inhibiting this enzyme, Mutant IDH1-IN-3 effectively reduces the production of D-2-hydroxyglutaric acid (2HG) in cellular models. This compound is particularly valuable in cancer research, providing insights into metabolic alterations and therapeutic strategies targeting IDH1 mutations.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1648909-73-2
Applications	Mutant IDH1 Inhibitor
Formula	C₂₂H₃₀N₄O
Molecular Weight	366.50
SMILES	OC1=C(CN2C=CN=C2)C=C(C(C)(C)CC(C)(C)C)C=C1CN3C=CN=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.