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MW073

5-HT2BR Antagonist

MW073 is a potent and selective antagonist of the 5-HT2B receptor, exhibiting an IC50 of 70 nM. This compound inhibits receptor activity and β-arrestin-1 recruitment in a concentration-dependent manner. MW073 has demonstrated the ability to improve synaptic plasticity and alleviate behavioral deficits, including aggression, in mouse models of Alzheimer’s disease. It is suitable for research applications focused on Alzheimer’s disease and related neurological conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	3048608-87-0
Applications	5-HT2BR Antagonist
Formula	C₂₂H₂₇N₅
Molecular Weight	361.48
SMILES	CN1CCN(CC1)CCNC2=NN=C(C=C2C)C3=CC=C4C=CC=CC4=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.