Fig. 1 · Structure
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Mycophenolate mofetil (hydrochloride)
Immunosuppressant
Mycophenolate mofetil (hydrochloride) is an oral immunosuppressant that acts primarily by inhibiting de novo purine synthesis, leading to significant reductions in B and T lymphocyte proliferation, as well as smooth muscle cell activity. This compound demonstrates potent antiproliferative and anti-inflammatory properties, making it valuable in research on allograft arteriosclerosis and chronic rejection mechanisms. Mycophenolate mofetil hydrochloride effectively mitigates adventitial inflammation, medial necrosis, and intimal thickening in rat aortic allograft models, and it can influence lymphocyte IL-2 receptor expression. Additionally, this compound has been shown to exhibit certain toxicity when combined with FK506 in specific xenotransplantation studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 116680-01-4 |
| Applications | Immunosuppressant |
| Formula | C23H32ClNO7 |
| Molecular Weight | 469.96 |
| Synonyms | RS 61443 (hydrochloride); TM-MMF (hydrochloride) |
| SMILES | O=C(OCCN1CCOCC1)CC/C(C)=C/CC2=C(O)C3=C(COC3=O)C(C)=C2OC.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.