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Mycothiazole

ETC Inhibitor

Mycothiazole is a potent inhibitor of mitochondrial electron transport chain complex I, demonstrating significant cytotoxic effects in various cancer cell lines, including Huh7 (IC50 = 55.8 μM), U87, and MCF7. In Huh7 cells, Mycothiazole induces apoptosis and activates the unfolded protein response (UPR) and heat shock response (HSR) pathways via transcription factors ATFS-1 and HSF1. This compound is valuable for research applications focused on cancer biology, mitochondrial dysfunction, and the study of cellular stress responses.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	114582-75-1
Applications	ETC Inhibitor
Formula	C₂₂H₃₂N₂O₃S
Molecular Weight	404.57
SMILES	COC(NCCC(/C=C\C[C@H](O)C(C)(C1=NC(C/C=C\CC=C)=CS1)C)=C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.