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MZ82

ATP-binding Cassette Subfamily G member 2 Inhibitor

MZ82 is a potent inhibitor of the ATP-binding cassette subfamily G member 2 (ABCG2/BCRP), exhibiting an IC50 of approximately 23 nM. This compound demonstrates significantly enhanced metabolic stability compared to its predecessor, Ko 143, in both liver microsomes and in vivo mouse models. Additionally, MZ82 is capable of penetrating the blood-brain barrier, making it a valuable tool for research applications focused on drug transport and pharmacokinetics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2944457-11-6
Applications	ATP-binding Cassette Subfamily G member 2 Inhibitor
Formula	C₂₆H₂₉N₃O₃
Molecular Weight	431.53
SMILES	O=C1N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CC(C)C)C4=C(C5=CC=C(OC)C=C5N4)C[C@H]31)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.