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N-(6S)-6-Carboxy-6-(glycylamino)hexanoyl-D-alanyl-D-alanine

Catalog No.: A86161
Polypeptide
N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine is designed to interact with the PAICS protein, thereby inhibiting its activity. This compound effectively decreases the accumulation of SAICAR and SAICAr, making it a valuable tool in metabolic and biochemical research focused on purine biosynthesis. Its ability to modulate these pathways can aid in studies related to cancer metabolism and other disorders associated with nucleotide imbalances.
N-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine 306748-45-8 Polypeptide
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN-[(6S)-6-Carboxy-6-(glycylamino)hexanoyl]-D-alanyl-D-alanine is designed to interact with the PAICS protein, thereby inhibiting its activity. This compound effectively decreases the accumulation of SAICAR and SAICAr, making it a valuable tool in metabolic and biochemical research focused on purine biosynthesis. Its ability to modulate these pathways can aid in studies related to cancer metabolism and other disorders associated with nucleotide imbalances.
Product Information
Catalog NumA86161
FormulaC15H26N4O7
Molecular Weight374.39
CAS Number306748-45-8
SMILES[C@@H](CCCCC(N[C@@H](C(N[C@@H](C(O)=O)C)=O)C)=O)(NC(CN)=O)C(O)=O
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