Fig. 1 · Structure
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N-Acetylserine
C3b Inhibitor
N-Acetylserine serves as a complement pathway modulator by targeting the activated third complement protein, C3b. It inhibits the covalent binding of glycerol to C3b's exposed thioester group through its reactive hydroxyl group. This compound is predominantly found in the soluble proteins of mammalian cells, contributing approximately 80% to such proteins. N-Acetylserine's blocking property can hinder direct Edman sequencing of proteins, though it can be removed through trifluoroacetic acid-catalyzed N→O acetyl migration followed by β-elimination, making it a valuable reagent for protein analysis with N-terminal acetylserine modifications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 16354-58-8 |
| Applications | C3b Inhibitor |
| Formula | C5H9NO4 |
| Molecular Weight | 147.13 |
| Synonyms | N-Acetyl-L-serine |
| SMILES | OC[C@@H](C(O)=O)NC(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.