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N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride

Serine Protease Inhibitor

N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride is a potent irreversible inhibitor of serine proteases, effectively targeting trypsin and trypsin-like proteases through the alkylation of histidine residues in their active sites. This compound also inhibits key apoptotic proteins, specifically caspase-3, caspase-6, and caspase-7, with respective IC50 values of 12.0, 54.5, and 19.3 μM. N-alpha-Tosyl-Lys chloromethyl ketone hydrochloride has demonstrated the ability to induce apoptosis in HL-60 cells while preventing the loss of mitochondrial transmembrane potential during the apoptotic process, making it valuable for studies on cell death pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	4238-41-9
Applications	Serine Protease Inhibitor
Formula	C₁₄H₂₂Cl₂N₂O₃S
Molecular Weight	369.31
Synonyms	TLCK hydrochloride
SMILES	O=S(C1=CC=C(C)C=C1)(NC(C(CCl)=O)CCCCN)=O.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.