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N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone

Acylated Homoserine Lactone

N-cis-Dodec-5(Z)-enoyl-L-homoserine lactone (5-cis-C12-HSL) is an acylated homoserine lactone that targets quorum sensing pathways. This compound is known to restore protease and pyoverdin production in an AHL-deficient Pseudomonas aeruginosa PAO1 lasI rhlI double mutant, demonstrating its role in bacterial communication. Although it exhibits minimal antibacterial activity and cytotoxicity towards tumor cells, its applications in studying quorum sensing and biofilm formation make it a valuable reagent for microbial and biomedical research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	945495-73-8
Applications	Acylated Homoserine Lactone
Formula	C₁₆H₂₇NO₃
Molecular Weight	281.39
Synonyms	5-cis-C12-HSL
SMILES	CCCCCC/C=C\CCCC(N[C@@H]1C(OCC1)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.