Fig. 1 · Structure
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N-Desmethyl Sildenafil
Sildenafil Metabolite
N-Desmethyl Sildenafil is an active metabolite of the well-known phosphodiesterase type 5 (PDE5) inhibitor, Sildenafil. This compound retains significant biological activity, contributing to the vasodilatory effects associated with PDE5 inhibition. Research applications include studies on erectile dysfunction and pulmonary hypertension, as well as the investigation of metabolic pathways involving Sildenafil.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 139755-82-1 |
| Applications | Sildenafil Metabolite |
| Formula | C21H28N6O4S |
| Molecular Weight | 460.55 |
| Synonyms | Desmethylsildenafil; UK-103,320 |
| SMILES | CCOC1=C(C=C(S(N2CCNCC2)(=O)=O)C=C1)C3=NC4=C(C(N3)=O)N(C)N=C4CCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.