N-Desmethylclozapine-d8 hydrochloride is a deuterated form of N-Desmethylclozapine hydrochloride, an important active metabolite of the atypical antipsychotic Clozapine. This compound acts as a potent allosteric and partial agonist of M1 receptors (EC50 = 115 nM) and enhances hippocampal N-methyl-D-aspartate (NMDA) receptor currents via M1 receptor activation. Additionally, N-Desmethylclozapine-d8 exhibits δ-opioid agonist activity, making it valuable for research in neuropharmacology and receptor signaling pathways.
N-Desmethylclozapine-d8 hydrochloride is a deuterated form of N-Desmethylclozapine hydrochloride, an important active metabolite of the atypical antipsychotic Clozapine. This compound acts as a potent allosteric and partial agonist of M1 receptors (EC50 = 115 nM) and enhances hippocampal N-methyl-D-aspartate (NMDA) receptor currents via M1 receptor activation. Additionally, N-Desmethylclozapine-d8 exhibits δ-opioid agonist activity, making it valuable for research in neuropharmacology and receptor signaling pathways.
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