Fig. 1 · Structure
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N-Desmethylclozapine-d8 hydrochloride
Stable Isotope
N-Desmethylclozapine-d8 hydrochloride is a deuterated form of N-Desmethylclozapine hydrochloride, an important active metabolite of the atypical antipsychotic Clozapine. This compound acts as a potent allosteric and partial agonist of M1 receptors (EC50 = 115 nM) and enhances hippocampal N-methyl-D-aspartate (NMDA) receptor currents via M1 receptor activation. Additionally, N-Desmethylclozapine-d8 exhibits δ-opioid agonist activity, making it valuable for research in neuropharmacology and receptor signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2705402-91-9 |
| Applications | Stable Isotope |
| Formula | C17H10D8Cl2N4 |
| Molecular Weight | 357.31 |
| Synonyms | Norclozapine-d8 hydrochloride; Desmethylclozapine-d8 hydrochloride; Normethylclozapine-d8 hydrochloride |
| SMILES | ClC1=CC=C2NC3=CC=CC=C3C(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=NC2=C1.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.