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N-Methyl-desamino lenalidomide-NH2

Ligand for E3 Ligase

N-Methyl-desamino lenalidomide-NH2 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), playing a crucial role in targeted protein degradation. This compound facilitates the recruitment of cereblon to specific target proteins, enabling the development of PROTACs (proteolysis-targeting chimeras) for precision research applications. It serves as a valuable tool for studying proteasomal degradation pathways and expanding the scope of targeted therapies in drug discovery.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2763749-29-5
Applications	Ligand for E3 Ligase
Formula	C₁₄H₁₅N₃O₃
Molecular Weight	273.29
SMILES	O=C1C2=CC(N)=CC=C2CN1C3C(=O)N(C(=O)CC3)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.