Fig. 1 · Structure
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N-Nitrosometoprolol
N-nitroso
N-Nitrosometoprolol is an N-nitroso derivative of the β-adrenergic blocker metoprolol, formed through a reaction with sodium nitrite. This compound exhibits the ability to induce micronuclei formation in rat liver, bone marrow, and spleen, making it relevant for studies on genotoxicity and the assessment of carcinogenic potential of pharmaceutical agents. It serves as a valuable reagent for research applications involving nitrosation and its biological consequences.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 138768-62-4 |
| Applications | N-nitroso |
| Formula | C15H24N2O4 |
| Molecular Weight | 296.36 |
| SMILES | OC(COC1=CC=C(C=C1)CCOC)CN(C(C)C)N=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.