Fig. 1 · Structure
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N-Nornuciferine
Cytochrome P450 Inhibitor
N-Nornuciferine is an aporphine alkaloid derived from lotus leaves that selectively inhibits the cytochrome P450 enzyme CYP2D6, with an IC50 value of 3.76 μM and a Ki of 2.34 μM. This compound plays an important role in pharmacological research by modulating drug metabolism and interactions. Its potency as a CYP2D6 inhibitor makes it a valuable tool for studies investigating drug efficacy and toxicity related to cytochrome P450 enzymatic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 4846-19-9 |
| Applications | Cytochrome P450 Inhibitor |
| Formula | C18H19NO2 |
| Molecular Weight | 281.35 |
| SMILES | COC1=C(OC)C2=C3C(CCN[C@]3([H])CC4=CC=CC=C24)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.