Fig. 1 · Structure
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N-Propargylglycine
PRODH Inhibitor
N-Propargylglycine is a potent inhibitor of proline dehydrogenase (PRODH). This inhibitor covalently modifies enzyme-bound FAD and active site lysine, leading to structural alterations, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. N-Propargylglycine is involved in mitochondrial stress responses and enhances mitochondrial chaperone levels, thereby promoting proteostasis. It has demonstrated efficacy in models of Huntington's disease, reducing hyperoxaluria, preventing calcium oxalate stone formation, and improving kidney health in Grhpr knockout mice. N-Propargylglycine shows promise in research focused on neurodegenerative disorders, breast cancer, and metabolic syndromes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 58160-95-5 |
| Applications | PRODH Inhibitor |
| Formula | C5H7NO2 |
| Molecular Weight | 113.11 |
| SMILES | O=C(O)CNCC#C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.