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N3-CMC

Click Chemistry Reagent

N3-CMC is a click chemistry reagent featuring an azide group that facilitates ring strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing molecules. Additionally, N3-CMC can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynes. This reagent specifically reacts with pseudouridine (Ψ)-containing RNA, enabling the biotin conjugation to N3-CMC-Ψ RNA through click chemistry. This application allows for the quantitative analysis of dynamic changes in Ψ, making it a valuable tool in RNA research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1801187-61-0
Applications	Click Chemistry Reagent
Formula	C₂₁H₃₂N₆O₄S
Molecular Weight	464.58
SMILES	C[N+]1(CCN=[C@@]=N[C@H]2CC[C@@H](N=[N+]=[N-])CC2)CCOCC1.O=S(C3=CC=C(C)C=C3)([O-])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.