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NA-17

Antitumor Agents

NA-17 is a naphthalimide compound that exerts its antitumor activity through p53-dependent mechanisms. It selectively inhibits various non-small cell lung cancer (NSCLC) cells while demonstrating reduced toxicity toward normal cells such as HL-7702 and WI-38. NA-17 induces the accumulation of active p53 in both mitochondria and nuclei, resulting in G1 phase cell cycle arrest, subsequent apoptosis, and cell death. This compound is valuable for research applications focusing on mechanisms of cancer cell proliferation and survival.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1708948-28-0
Applications	Antitumor Agents
Formula	C₂₆H₂₇N₃O₄
Molecular Weight	445.51
SMILES	O=C1C2=CC=CC3=C2C(C(N1CCC4=CC=C5OCOC5=C4)=O)=CC=C3NCCCN(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.