Fig. 1 · Structure
Documents & Downloads
NAB-14
GluN2C/2D Antagonists
NAB-14 is a selective, orally active non-competitive antagonist of GluN2C and GluN2D subunits, exhibiting an IC50 of 580 nM for the GluN1/GluN2D complex. With greater than 800-fold selectivity for GluN2C and GluN2D over GluN2A and GluN2B, this compound is suitable for investigating the roles of these NMDA receptor subtypes in neurobiology. Additionally, NAB-14's ability to cross the blood-brain barrier enables its use in preclinical studies related to central nervous system disorders.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1237541-73-9 |
| Applications | GluN2C/2D Antagonists |
| Formula | C20H21N3O3 |
| Molecular Weight | 351.40 |
| SMILES | O=C(OC1=CC=C(C(NC2=CC=CC3=C2NC=C3)=O)C=C1)N(CC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.