Fig. 1 · Structure
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nAChR agonist CMPI hydrochloride
nAChR Agonist
nAChR agonist CMPI hydrochloride is a selective positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs) featuring the α4:α4 subunit interface. It significantly enhances the activity of the (α4)3(β2)2 nAChR in response to acetylcholine, with an EC50 value of 0.26 µM. This compound is valuable for research into nicotine dependence and various neuropsychiatric disorders linked to reduced cholinergic activity in the brain.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2250025-94-4 |
| Applications | nAChR Agonist |
| Formula | C18H20Cl2N4O |
| Molecular Weight | 379.28 |
| SMILES | CC1=C(C2=CC(C3=CC=CC=C3Cl)=NO2)C=NN1C4CCNCC4.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.