nAChR agonist CMPI hydrochloride is a selective positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs) featuring the α4:α4 subunit interface. It significantly enhances the activity of the (α4)3(β2)2 nAChR in response to acetylcholine, with an EC50 value of 0.26 µM. This compound is valuable for research into nicotine dependence and various neuropsychiatric disorders linked to reduced cholinergic activity in the brain.
nAChR agonist CMPI hydrochloride is a selective positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs) featuring the α4:α4 subunit interface. It significantly enhances the activity of the (α4)3(β2)2 nAChR in response to acetylcholine, with an EC50 value of 0.26 µM. This compound is valuable for research into nicotine dependence and various neuropsychiatric disorders linked to reduced cholinergic activity in the brain.
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