Fig. 1 · Structure
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nAChR antagonist 1
nAChR Antagonist
nAChR antagonist 1 is a selective antagonist of the α7 nicotinic acetylcholine receptor, exhibiting an IC50 value of 3.3 μM. This compound is valuable for studying the role of α7 nAChR in various neurological conditions, including schizophrenia, Alzheimer's disease, and inflammatory disorders. Its modulatory effects on neurotransmission make it a relevant tool for exploring therapeutic strategies in these disease contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2987393-37-1 |
| Applications | nAChR Antagonist |
| Formula | C19H22N4O2 |
| Molecular Weight | 338.40 |
| SMILES | COC1=CC(C2=CC=C(C=C2)C3=NOC4(N3)CCN(CC4)C)=CC=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.