Fig. 1 · Structure
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NAG-thiazoline
O-GlcNAcase Inhibitor
NAG-thiazoline is a potent inhibitor of O-GlcNAcase, exhibiting a Ki of 180 nM. This compound effectively inhibits the GH20 GlcNAcase (VhGlcNAcase) with an IC50 value of 11.9 μM. NAG-thiazoline is valuable for research applications involving glycosylation processes and the exploration of O-GlcNAc signaling pathways in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 179030-22-9 |
| Applications | O-GlcNAcase Inhibitor |
| Formula | C8H13NO4S |
| Molecular Weight | 219.26 |
| SMILES | O[C@@H]1[C@]2([H])[C@](SC(C)=N2)([H])O[C@@H]([C@H]1O)CO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.