Fig. 1 · Structure
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Naldemedine tosylate
μ-opioid Receptor Antagonist
Naldemedine tosylate is a selective μ-opioid receptor antagonist, classified as a peripherally acting mu-opioid receptor antagonist (PAMORA). It exhibits high binding affinities for human μ-, δ-, and κ-opioid receptors, making it a valuable reagent for studying opioid-related pathways. Its primary application includes research on opioid-induced constipation (OIC). Additionally, Naldemedine tosylate has the potential to interact with the 3CLpro protease encoded by the SARS-CoV2 genome, suggesting further avenues for investigation in viral studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1345728-04-2 |
| Applications | μ-opioid Receptor Antagonist |
| Formula | C39H42N4O9S |
| Molecular Weight | 742.84 |
| Synonyms | S-297995 tosylate |
| SMILES | O[C@@]1(CC(C(NC(C)(C2=NC(C3=CC=CC=C3)=NO2)C)=O)=C4O)[C@@]([C@@]4([H])OC5=C6O)(CC7)C5=C(C=C6)C[C@@]1([H])N7CC8CC8.CC9=CC=C(S(=O)(O)=O)C=C9 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.