Fig. 1 · Structure
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NAPQI
Acetaminophen Metabolite
NAPQI (N-acetyl-p-benzoquinone imine) is a toxic metabolite of acetaminophen that primarily targets glutathione and cysteine residues in proteins. Under normal conditions, NAPQI is detoxified by glutathione, but in cases of glutathione depletion, it can lead to oxidative stress and cell death, particularly in hepatic tissues. NAPQI is significant in studies related to acetaminophen toxicity and the mechanisms of liver injury, making it a valuable tool for biochemical research and toxicology applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 50700-49-7 |
| Applications | Acetaminophen Metabolite |
| Formula | C8H7NO2 |
| Molecular Weight | 149.15 |
| Synonyms | N-Acetyl-4-benzoquinone Imine |
| SMILES | CC(/N=C1C=CC(C=C\1)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.