Fig. 1 · Structure
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NaV1.2/1.6 channel blocker-1
NaV1.2/1.6 Channel Blocker
NaV1.2/1.6 channel blocker-1 is a selective inhibitor of the NaV1.2 and NaV1.6 sodium channels, exhibiting IC50 values of 9.8 μM for rNaV1.6 and 24.4 μM for hNaV1.2. This compound is valuable for studying the role of sodium channels in neuronal excitability and has potential applications in the research of generalized epilepsy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1199944-04-1 |
| Applications | NaV1.2/1.6 Channel Blocker |
| Formula | C14H14N2OS |
| Molecular Weight | 258.34 |
| SMILES | S=C1OC2=CC=CC=C2C3=NC(C)=C(CCC)N13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.