Fig. 1 · Structure
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Navafenterol saccharinate
M3 Antagonist/β2 Agonist
Navafenterol saccharinate is a potent, selective M3 receptor antagonist and β2-adrenoceptor agonist, exhibiting dual action with long-lasting effects. With a pIC50 of 9.5 for the human M3 receptor and a pEC50 of 9.5 for the β2-adrenoceptor, this compound demonstrates significant bronchoprotective and antisialagogue properties. Navafenterol saccharinate is primarily utilized in research focused on chronic obstructive pulmonary disease (COPD) and offers a favorable cardiovascular safety profile.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1648550-37-1 |
| Applications | M3 Antagonist/β2 Agonist |
| Formula | C45H47N7O9S3 |
| Molecular Weight | 926.09 |
| Synonyms | AZD-8871 saccharinate; LAS191351 saccharinate |
| SMILES | O=C(C(O)(C1=CC=CS1)C2=CC=CS2)O[C@H]3CC[C@@H](CC3)N(C)CCCN4N=NC5=CC(CNC[C@H](O)C6=CC=C(C7=C6C=CC(N7)=O)O)=CC=C54.O=S8(C9=CC=CC=C9C(N8)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.