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Navafenterol

M3 Antagonist/β2 Agonist

Navafenterol is a potent and selective M3 antagonist and β2 agonist, designed for inhalation therapy. It exhibits a high affinity for the human M3 receptor with a pIC50 of 9.5 and demonstrates a pEC50 of 9.5 for the β2-adrenoceptor, highlighting its dual mechanism of action. This compound is primarily utilized in research focused on chronic obstructive pulmonary disease (COPD), delivering bronchoprotective and antisialagogue effects while maintaining a favorable cardiovascular profile.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1435519-06-4
Applications	M3 Antagonist/β2 Agonist
Formula	C₃₈H₄₂N₆O₆S₂
Molecular Weight	742.91
Synonyms	AZD-8871; LAS191351
SMILES	O=C(C(O)(C1=CC=CS1)C2=CC=CS2)O[C@H]3CC[C@@H](CC3)N(C)CCCN4N=NC5=CC(CNC[C@H](O)C6=CC=C(C7=C6C=CC(N7)=O)O)=CC=C54

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.