Fig. 1 · Structure
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Navocaftor
Cystic Fibrosis Transmembrane Regulator
Navocaftor is a small molecule modulator of the Cystic Fibrosis Transmembrane Regulator (CFTR) protein. It enhances the function of the CFTR protein to improve chloride ion transport across epithelial cell membranes. This compound is primarily utilized in research focusing on cystic fibrosis therapies, assessing the efficacy of CFTR modulators, and studying related ion channel functionalities in various models of disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2159103-66-7 |
| Applications | Cystic Fibrosis Transmembrane Regulator |
| Formula | C15H11F3N4O5S |
| Molecular Weight | 416.33 |
| Synonyms | GLPG 3067; ABBV-3067 |
| SMILES | OCC1=NN=C(C2=NC=C(S(=O)(C3=CC=C(OC(F)(F)F)C=C3)=O)C=C2N)O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.