Fig. 1 · Structure
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NBI 30545
CRF1R Antagonist
NBI 30545 is a selective antagonist of the corticotropin-releasing factor 1 receptor (CRF1R), demonstrating a Ki value of 3.4 nM for the human receptor. This compound effectively inhibits CRF-stimulated intracellular cAMP accumulation and subsequent ACTH release. NBI 30545 is valuable for research focusing on depression, anxiety disorders, and stress-related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 195054-99-0 |
| Applications | CRF1R Antagonist |
| Formula | C22H30N4O3 |
| Molecular Weight | 398.51 |
| SMILES | N1=C(C=C(N2N=C(C(=C12)C=3C=CC(OC)=CC3OC)C)N(CCOC)CCC)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.