Fig. 1 · Structure
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NBI 35965 hydrochloride
CRF1 Antagonist
NBI 35965 hydrochloride is a selective and orally active antagonist of corticotropin-releasing factor receptor 1 (CRF1), exhibiting a Ki value of 4 nM and a pKi value of 8.5. This compound specifically inhibits CRF1 without affecting CRF2 and effectively reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo, with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride demonstrates anxiolytic properties, making it a valuable tool for research into stress-related disorders and neurobiology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1782228-59-4 |
| Applications | CRF1 Antagonist |
| Formula | C21H23Cl3N4 |
| Molecular Weight | 437.79 |
| SMILES | CC[C@H]1CN2N=C(C3=C(C=C(C=C3)Cl)Cl)C4=NC(C)=CC(N1CC5CC5)=C42.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.