Fig. 1 · Structure
Documents & Downloads
NBI 35965 methanesulfonate
CRF1 Antagonist
NBI 35965 methanesulfonate is a selective corticotropin-releasing factor receptor 1 (CRF1) antagonist, exhibiting a Ki value of 4 nM and a pKi value of 8.5, while sparing CRF2. This compound effectively diminishes both CRF and stress-induced adrenocorticotropic hormone (ACTH) production in vivo, with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate is utilized in research focused on anxiety and stress-related disorders, demonstrating pronounced anxiolytic effects.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 603151-83-3 |
| Applications | CRF1 Antagonist |
| Formula | C22H26Cl2N4O3S |
| Molecular Weight | 497.44 |
| SMILES | CC1=CC2=C3N(N=C(C4=CC=C(Cl)C=C4Cl)C3=N1)C[C@H](CC)N2CC5CC5.OS(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.