Fig. 1 · Structure
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NBI-961
NEK2 Inhibitor
NBI-961 is a potent inhibitor of NEK2, a serine/threonine kinase involved in cell cycle regulation. By inhibiting proteasomal degradation, NBI-961 effectively induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells. This compound serves as a valuable tool for research into the therapeutic targeting of NEK2 in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2225902-98-5 |
| Applications | NEK2 Inhibitor |
| Formula | C28H27F3N6O2S |
| Molecular Weight | 568.61 |
| SMILES | CC(C1=C(C=CC=C1)C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(CCN(C)C)N=C5)=C2)C(N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.