Fig. 1 · Structure
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NCAO
ODC Inhibitor
N-ω-chloroacetyl-L-ornithine (NCAO) functions as a potent reversible competitive inhibitor of ornithine decarboxylase (ODC). This compound demonstrates significant cytotoxic and antiproliferative activity across various tumor cell lines, with effective concentrations (EC50) ranging from 1 to 50.6 µM. NCAO induces apoptosis in tumor cells and inhibits their migration in vitro. Additionally, it displays strong antitumor effects in vivo, notably against both solid and ascitic tumors in a mouse model utilizing the myeloma (Ag8) cell line, making it a valuable candidate for research into novel antitumor agents.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 20584-81-0 |
| Applications | ODC Inhibitor |
| Formula | C7H13ClN2O3 |
| Molecular Weight | 208.64 |
| SMILES | OC([C@@H](N)CCCNC(CCl)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.