Fig. 1 · Structure
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NCATS-SM4487
GALK1 Inhibitor
NCATS-SM4487 is a selective dihydropyrimidine compound that inhibits galactokinase 1 (GALK1) with an IC50 value of 0.05 μM. By targeting GALK1, it plays a pivotal role in regulating galactose metabolism. This compound is valuable for research applications focusing on galactosemia and metabolic disorders related to carbohydrate metabolism.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2733617-81-5 |
| Applications | GALK1 Inhibitor |
| Formula | C25H24ClFN8O2 |
| Molecular Weight | 522.96 |
| SMILES | CN1C=C(C=N1)CNC(C2=C(NC(NC3=NC4=C(C(N)=C(C=C4)F)O3)=NC2C5=C(C=C(C=C5)C)Cl)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.