Fig. 1 · Structure
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NCGC00029283
WRN Helicase Inhibitor
NCGC00029283 is a potent inhibitor of Werner syndrome helicase-nuclease (WRN), exhibiting an IC50 of 2.3 μM for WRN helicase, along with IC50s of 12.5 μM and 3.4 μM for BLM and FANCJ helicases, respectively. This compound is valuable for studying the roles of helicases in DNA repair and replication pathways. It is particularly relevant for research on cellular mechanisms associated with Werner syndrome and various cancers linked to helicase dysfunction.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 714240-31-0 |
| Applications | WRN Helicase Inhibitor |
| Formula | C18H12FN3O3 |
| Molecular Weight | 337.30 |
| SMILES | O=C1NC2=C(C=C(OC)C=C2)C=C1C3=NOC(C4=CC=C(F)C=C4)=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.