Fig. 1 · Structure
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NCGC00229600
TSHR Inverse Agonist
NCGC00229600 is an allosteric inverse agonist of the thyrotropin receptor (TSHR). It effectively inhibits the activation of TSH receptors, including both thyrotropin and stimulating antibodies, which is particularly relevant for studies involving Graves' disease. This compound is valuable for research applications focused on thyroid hormone signaling and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 1338824-20-6 |
| Applications | TSHR Inverse Agonist |
| Formula | C30H29N3O3 |
| Molecular Weight | 479.57 |
| SMILES | O=C1N(CC2=CC=CN=C2)C(C3=CC=C(OC)C(COC4=C(C)C=CC=C4C)=C3)NC5=C1C=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.