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Biological Activity
ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.59 mL | 87.93 mL | 175.86 mL |
0.5 mM | 3.52 mL | 17.59 mL | 35.17 mL |
1 mM | 1.76 mL | 8.79 mL | 17.59 mL |
5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
*The above data is based on the productmolecular weight 568.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A20079 |
---|---|
Actions | Inhibitor |
CAS No. | 1434639-57-2 |
Formula | C28H32N4O7S |
M. Wt | 568.64 |
Purity | >98% |
Synonyms | ND 646; ND646 |
SMILES | O=C(N)C(C)(C)N(C(N(C[C@@H](C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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