Fig. 1 · Structure
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ND-654
ACC Inhibitor
ND-654 is a potent and selective inhibitor of acetyl-CoA carboxylase (ACC), exhibiting IC50 values of 3 nM for ACC1 and 8 nM for ACC2. This compound effectively reduces hepatic lipogenesis, diminishes neutrophil recruitment, and enhances the polarization of anti-inflammatory M2 macrophages. ND-654 holds potential for investigations into nonalcoholic steatohepatitis and hepatocellular carcinoma research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1434641-55-0 |
| Applications | ACC Inhibitor |
| Formula | C29H33N3O8S |
| Molecular Weight | 583.65 |
| SMILES | CC(C)(N(C(N(C[C@H](O[C@H]1CC[C@@H](O)CC1)C2=CC=CC=C2OC)C3=C4C(C)=C(C5=NC=CO5)S3)=O)C4=O)C(O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.