Fig. 1 · Structure
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NDMC101
Osteoclastogenesis Inhibitor
NDMC101 is a potent osteoclastogenesis inhibitor that targets the differentiation of osteoclasts by down-regulating NFATc1-modulated gene expression. In addition to its role in inhibiting osteoclast differentiation, NDMC101 also significantly inhibits early T-cell activation through DPP4 inhibition. This compound is useful for research applications related to bone disorders, such as rheumatoid arthritis, and synovial inflammation, facilitating the exploration of therapeutic strategies in these areas.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1308631-40-4 |
| Applications | Osteoclastogenesis Inhibitor |
| Formula | C13H9ClFNO2 |
| Molecular Weight | 265.67 |
| SMILES | OC1=C(C=CC=C1)C(NC2=CC=C(C=C2F)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.