Fig. 1 · Structure
Documents & Downloads
Nec-3a
RIP1 Inhibitor
Nec-3a is a potent inhibitor of receptor-interacting protein kinase 1 (RIP1), displaying an IC50 value of 0.44 μM. This compound effectively inhibits the autophosphorylation activity of the RIP1 kinase domain, making it a valuable tool in the study of necroptosis and cell death signaling pathways. Nec-3a is useful in various research applications, particularly in investigating RIP1's role in inflammation, neurodegeneration, and cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1504558-72-8 |
| Applications | RIP1 Inhibitor |
| Formula | C21H18F4N2O4 |
| Molecular Weight | 438.37 |
| SMILES | COC1=CC=C2CC[C@H]3[C@@H](C4=CC=C(C(F)=C4)OC(F)(F)F)N(C(CO)=O)N=C3C2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.