Fig. 1 · Structure
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Necrocide 1
NECSO Inducer
Necrocide 1 is a sodium overload (NECSO) inducer that acts as a selective agonist for the transient receptor potential melastatin 4 (TRPM4) channel, with an EC50 of 306.3 nM in human TRPM4. It promotes TRPM4-mediated necrotic cell death by facilitating sodium influx, leading to immunogenic cell death characterized by calreticulin (CALR) surface exposure, ATP release, and high mobility group box 1 (HMGB1) secretion. This compound is valuable for research in breast and prostate cancer studies, providing insights into the mechanisms of necrosis and immune response modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 1247028-61-0 |
| Applications | NECSO Inducer |
| Formula | C23H27NO3 |
| Molecular Weight | 365.47 |
| SMILES | O=C1NC2=C(C=CC(OC)=C2C)[C@]1(C3CCCCCC3)C4=CC=C(O)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.