Necrostatin-34 is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1). It stabilizes the inactive conformation of RIPK1 by binding to a specific pocket within the kinase domain, thereby preventing its activation. This compound is primarily utilized in research to explore necroptosis and cell death pathways, making it valuable for studies in inflammation, neurodegeneration, and cancer.
Necrostatin-34 is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1). It stabilizes the inactive conformation of RIPK1 by binding to a specific pocket within the kinase domain, thereby preventing its activation. This compound is primarily utilized in research to explore necroptosis and cell death pathways, making it valuable for studies in inflammation, neurodegeneration, and cancer.
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