Fig. 1 · Structure
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Necrostatin-5
Necroptosis/RIP1 Inhibitor
Necrostatin-5 (Nec-5) is a potent inhibitor of necroptosis, acting primarily through the inhibition of receptor-interacting protein kinase 1 (RIP1) with an EC50 of 0.24 µM. It exhibits significant cardioprotective effects, making it valuable for research in cell death mechanisms and cardiovascular studies. This reagent is useful for investigations into necroptotic pathways and their implications in various diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 337349-54-9 |
| Applications | Necroptosis/RIP1 Inhibitor |
| Formula | C19H17N3O2S2 |
| Molecular Weight | 383.49 |
| Synonyms | Nec-5 |
| SMILES | O=C(N1C2=CC=C(C=C2)OC)C3=C(N=C1SCC#N)SC4=C3CCCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.