Fig. 1 · Structure

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Neferine

Cat. No. A14743 CAS 2292-16-2
Neferine is the major bisbenzylisoquinoline alkaloid isolated from the seed embryo of a traditional medicinal plant Nelumbo nucifera (Lotus).

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Biological Activity

Target & Activity

Target Activity Value
p65  
Autophagy  

Cellular Effect

Cell Line Activity Value Description Reference
ECa-109 cell line IC50 3794 nM Reversal of VCR -resistance in human Eca-109 cells assessed as cell viability at 5 uM incubated for 48 hrs by CCK-8 method (Rvb = 6830.0+/-537.0 nM) [PMID: 36892076]

Specifications

Manufacturer Adooq Bioscience
CAS Number 2292-16-2
Formula C38H44N2O6
Molecular Weight 624.77
SMILES
CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 88 mg/mL (140.84 mM)

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Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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