Fig. 1 · Structure
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Nek2/Hec1-IN-1
Drug Derivative
Nek2/Hec1-IN-1 is a derivative of INH1 that targets the Nek2 protein, exhibiting significant anticancer activity. It demonstrates cytotoxic effects on various cancer cell lines, including MDA-MB-231, MDA-MB-488, HeLa, and K562, with IC50 values of 1.1, 3.4, 1.6, and 1.2 μM, respectively. This compound is valuable for research applications focused on cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 560103-80-2 |
| Applications | Drug Derivative |
| Formula | C17H15N3OS |
| Molecular Weight | 309.39 |
| Synonyms | Nec2/Hec1 inhibitor |
| SMILES | O=C(C1=CC=NC=C1)NC2=NC(C3=CC=C(C)C=C3C)=CS2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.