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Nemolizumab

Nemolizumab (CIM331) is a humanized monoclonal antibody designed to selectively target the interleukin-31 receptor alpha (IL-31RA). By binding to IL-31RA, Nemolizumab effectively inhibits the interaction between interleukin-31 (IL-31) and its receptor, thereby blocking the downstream signaling pathways. This inhibition is clinically relevant as it contributes to the reduction of pruritus (itching) and sleep disturbances associated with various dermatological conditions, including atopic dermatitis (AD). Nemolizumab is currently under investigation for its therapeutic potential and efficacy in treating symptoms of AD and related conditions.

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Product Details

Manufacturer Adooq Bioscience
Actions Antagonist
CAS Number 1476039-58-3
Molecular Weight 144920
Synonyms CIM331

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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