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NEP168

PROTAC ERα Degrader

NEP168 is a potent ERα PROTAC degrader that utilizes the GID4 E3 ligase for targeted protein degradation. This compound effectively reduces ERα levels, offering valuable insights into estrogen receptor-related signaling pathways. NEP168 serves as a crucial tool for investigating breast cancer biology and may aid in the development of novel therapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3031840-37-3
Applications	PROTAC ERα Degrader
Formula	C₅₁H₅₄N₆O₄
Molecular Weight	815.01
SMILES	CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)\C3=CC=C(C=C3)OCC(NCCCOC4=CC=C(N=C([C@H]5CC[C@H](CC5)NC(CNCC6=CC7=CC=CC=C7N6)=O)N8)C8=C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.