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Neratinib (HKI-272)

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HER2 inhibitor

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Catalog No. A10638

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Neratinib 5mg A10638-5

Regular Price: $50.00

Special Price: $45.00

Neratinib 10mg A10638-10

Regular Price: $75.00

Special Price: $67.50

Neratinib 25mg A10638-25

Regular Price: $100.00

Special Price: $90.00

Neratinib 100mg A10638-100

Regular Price: $220.00

Special Price: $198.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Neratinib (HKI-272) is a tyrosine kinase inhibitor.

Neratinib (HKI-272)

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Publications citing Adooq Products
Neratinib (HKI-272) Citations (1)
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961

Chemical Information

Catalog Num A10638
Actions Inhibitor
M. Wt 557.0
Formula C30H29ClN6O3
Solubility DMSO>4mg/mL Water<1mg/mL Ethanol>2mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 698387-09-6
Synonyms N/A
SMILES CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C

Biological Activity

Description
 Neratinib (HKI-272) is a tyrosine kinase inhibitor.
Targets
Target Value
HER2IC50: 59nM
EGFRIC50: 92nM
KDRIC50: 800nM
SrcIC50: 1.4μM
PDK-1IC50: >5μM
IKK2IC50: >9μM
CDK2/CyclinEIC50: >18μM
CDK1/CyclinB1IC50: >18μM
C-Raf/MEK1IC50: >18μM
Tpl-2IC50: >18μM
AktIC50: >20μM
c-MetIC50: >35μM
MK2IC50: >45μM
CDK4/CyclinD1IC50: >50μM

Solubility

Solubility (25°C) * In vitro DMSO 2 mg/mL (3.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.95 mL 89.77 mL 179.53mL
0.5 mM 3.59 mL 17.95 mL 35.91 mL
1 mM 1.8 mL 8.98 mL 17.95 mL
5 mM 0.36 mL 1.8 mL 3.59 mL

*The above data is based on the productmolecular weight 557.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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