Total item
Cart Subtotal
$0.00 Biological Activity
Neratinib (HKI-272) is a tyrosine kinase inhibitor.
Targets
| Target | Value |
|---|---|
| HER2 | IC50: 59nM |
| EGFR | IC50: 92nM |
| KDR | IC50: 800nM |
| Src | IC50: 1.4μM |
| PDK-1 | IC50: >5μM |
| IKK2 | IC50: >9μM |
| CDK2/CyclinE | IC50: >18μM |
| CDK1/CyclinB1 | IC50: >18μM |
| C-Raf/MEK1 | IC50: >18μM |
| Tpl-2 | IC50: >18μM |
| Akt | IC50: >20μM |
| c-Met | IC50: >35μM |
| MK2 | IC50: >45μM |
| CDK4/CyclinD1 | IC50: >50μM |
| In vitro (25°C) | DMSO | 2 mg/mL (3.59 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 30% PEG400/0.5% Tween80/5% propylene glycol | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.95 mL | 89.77 mL | 179.53 mL |
| 0.5 mM | 3.59 mL | 17.95 mL | 35.91 mL |
| 1 mM | 1.8 mL | 8.98 mL | 17.95 mL |
| 5 mM | 0.36 mL | 1.8 mL | 3.59 mL |
*The above data is based on the productmolecular weight 557.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10638 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 557.0 |
| Formula | C30H29ClN6O3 |
| Solubility | DMSO>4mg/mL Water<1mg/mL Ethanol>2mg/mL |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 698387-09-6 |
| SMILES | CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
ASP8273 (Naquotinib)
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with po…
OSI-420
OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by…
SU-5402
SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor…
AEE788
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, …
WHI-P180
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
Erlotinib HCl
Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
Keywords:buy Neratinib (HKI-272) | Neratinib (HKI-272) Supplier | purchase Neratinib (HKI-272) | Neratinib (HKI-272) cost | Neratinib (HKI-272) manufacturer | order Neratinib (HKI-272) | Neratinib (HKI-272) distributor | buy 698387-09-6| 698387-09-6 Supplier | purchase 698387-09-6 | 698387-09-6 cost | 698387-09-6 manufacturer | order 698387-09-6 | 698387-09-6 distributor
Adooq Quality Guarantee
We promise all products perform as described.