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Neratinib (HKI-272)

Catalog No.: A10638

HER2 inhibitor

Neratinib (HKI-272)

Neratinib (HKI-272) Chemical Structure

CAS NO. 698387-09-6

Neratinib (HKI-272) is a tyrosine kinase inhibitor.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961

Biological Activity

Neratinib (HKI-272) is a tyrosine kinase inhibitor.
Target Value
HER2IC50: 59nM
EGFRIC50: 92nM
KDRIC50: 800nM
SrcIC50: 1.4μM
PDK-1IC50: >5μM
IKK2IC50: >9μM
CDK2/CyclinEIC50: >18μM
CDK1/CyclinB1IC50: >18μM
C-Raf/MEK1IC50: >18μM
Tpl-2IC50: >18μM
AktIC50: >20μM
c-MetIC50: >35μM
MK2IC50: >45μM
CDK4/CyclinD1IC50: >50μM
In vitro (25°C) DMSO Warmed: 4 mg/mL (7.18 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.95 mL 89.77 mL 179.53 mL
0.5 mM 3.59 mL 17.95 mL 35.91 mL
1 mM 1.8 mL 8.98 mL 17.95 mL
5 mM 0.36 mL 1.8 mL 3.59 mL

*The above data is based on the productmolecular weight 557.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10638
Actions Inhibitor
CAS No. 698387-09-6
Formula C30H29ClN6O3
M. Wt 557.0
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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