Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Hamzehlou S, .et al. Anti-tumor activity of neratinib, a pan-HER inhibitor, in gastric adenocarcinoma cells, Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Biological Activity
Neratinib (HKI-272) is a tyrosine kinase inhibitor.
Targets
Target | Value |
---|---|
HER2 | IC50: 59nM |
EGFR | IC50: 92nM |
KDR | IC50: 800nM |
Src | IC50: 1.4μM |
PDK-1 | IC50: >5μM |
IKK2 | IC50: >9μM |
CDK2/CyclinE | IC50: >18μM |
CDK1/CyclinB1 | IC50: >18μM |
C-Raf/MEK1 | IC50: >18μM |
Tpl-2 | IC50: >18μM |
Akt | IC50: >20μM |
c-Met | IC50: >35μM |
MK2 | IC50: >45μM |
CDK4/CyclinD1 | IC50: >50μM |
In vitro (25°C) | DMSO | Warmed: 4 mg/mL (7.18 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 17.95 mL | 89.77 mL | 179.53 mL |
0.5 mM | 3.59 mL | 17.95 mL | 35.91 mL |
1 mM | 1.8 mL | 8.98 mL | 17.95 mL |
5 mM | 0.36 mL | 1.8 mL | 3.59 mL |
*The above data is based on the productmolecular weight 557.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10638 |
---|---|
Actions | Inhibitor |
CAS No. | 698387-09-6 |
Formula | C30H29ClN6O3 |
M. Wt | 557.0 |
Purity | >98% |
SMILES | CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
BIBW2992 (Afatinib)
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epider…
TAK-285
TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB). TAK-285 has inhi…
AG-18 (Tyrphostin 23)
AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 ,M in the human epidermoid carcinoma cell li…
WZ3146
WZ3146 is an inhibitor of EGFR receptor kinase mutants carrying a mutation in an active site gatekeeper residue (T790M) and is much less pot…
ARRY-543 (Varlitinib, ASLAN001)
ARRY-543 is a novel, oral ErbB family inhibitor that, unlike approved ErbB inhibitors, targets all members of the ErbB family, including Erb…
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
ASP8273 (Naquotinib)
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with po…
Keywords:buy Neratinib (HKI-272) | Neratinib (HKI-272) Supplier | purchase | cost | manufacturer | order | distributor | buy 698387-09-6| 698387-09-6 Supplier | purchase 698387-09-6 | 698387-09-6 cost | 698387-09-6 manufacturer | order 698387-09-6 | 698387-09-6 distributor