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NEURL1B-IN-1

NEURL1B Degrader

NEURL1B-IN-1 is a potent NEURL1B degrader with a Kd value of 46.2 nM. By specifically binding to Arg422 in the NHR2 domain of NEURL1B, this compound promotes autoubiquitination and subsequent proteasomal degradation of NEURL1B, effectively disrupting its interaction with DLL1 and inhibiting the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest and apoptosis while also inhibiting the migration of hepatocellular carcinoma cells, making it a valuable tool for research in hepatocellular carcinoma.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Degrader
CAS Number	3068938-30-4
Applications	NEURL1B Degrader
Formula	C₃₀H₃₈O₅
Molecular Weight	478.62
SMILES	[H][C@@]12C[C@H]3[C@H](OC([C@@]34C[C@@H]5C[C@]4(C6=C5[C@@](O)(CC[C@H]7C(C(O[C@H]67)=O)=C)C)C)=O)C[C@]1(CCCC2=C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.