Fig. 1 · Structure
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Neutrophil elastase inhibitor 3
Neutrophil Elastase Inhibitor
Neutrophil elastase inhibitor 3 is a benzoxazinone analog that selectively inhibits neutrophil elastase (NE) with an IC50 of 80.8 nM. Its inhibitory effects are linked to the reduction of superoxide anion generation, making it a valuable tool in studying neutrophil-mediated inflammatory responses. This compound is suitable for research applications focused on inflammatory diseases and the role of neutrophil elastase in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1234707-32-4 |
| Applications | Neutrophil Elastase Inhibitor |
| Formula | C14H7BrClNO2 |
| Molecular Weight | 336.57 |
| SMILES | O=C1OC(C2=CC=CC=C2Br)=NC3=CC=CC(Cl)=C13 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.